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Abrocitinib (PF-04965842)

Abrocitinib (PF-04965842)

Name: Abrocitinib (PF-04965842)
SKU: A18318

目录号: A18318

JAK1 抑制剂

Abrocitinib (PF-04965842) Chemical Structure

CAS NO. 1622902-68-4

Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease.

库存：现货

规格	价格	数量
5 mg	￥ 1,800.00
10 mg	￥ 3,200.00
50 mg	￥ 12,000.00

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产品详情

生物活性

溶解度 *

In vitro	DMSO	58 mg/mL (179.34 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	30.92 mL	154.6 mL	309.2 mL
0.5 mM	6.18 mL	30.92 mL	61.84 mL
1 mM	3.09 mL	15.46 mL	30.92 mL
5 mM	0.62 mL	3.09 mL	6.18 mL

*The above data is based on the productmolecular weight 323.415. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A18318
作用机制	Inhibitor (抑制剂)
M. Wt	323.415
Formula	C14H21N5O2S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1622902-68-4
Synonyms	PF04965842. PF 04965842
SMILES	CN([C@H]1C[C@@H](NS(CCC)(=O)=O)C1)C2=C3C(NC=C3)=NC=N2