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ABT-199 (Venetoclax)

促销

Bcl-2 抑制剂

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产品目录号: A12500

库存状态:中国现货中国现货

产品名 目录号 价格 数量
ABT-199 10mg A12500-10
¥ 1,200.00
ABT-199 25mg A12500-25
¥ 2,500.00
ABT-199 50mg A12500-50
¥ 5,200.00
ABT-199 100mg A12500-100
¥ 8,000.00
ABT-199 10mM * 1mL in DMSO A12500-10mM-D
¥ 1,630.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.

ABT-199 (Venetoclax)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 ABT-199 (Venetoclax) 发表的文献 (3)
  • Chauhan D, .et al. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1汕 Maturation in Macrophages, Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805
  • Martin Grundy, .et al. Predicting effective pro-apoptotic anti-leukaemic drug combinations using co-operative dynamic BH3 profiling, PLoS One, 2018, 13(1): e0190682 PMID: 29298347
  • Joanne Dai, .et al. Intracellular BH3 profiling reveals shifts in anti-apoptotic dependency in B-cell maturation and activation, J Immunol, 2018, 200 (5) 1727-1736 PMID: 29358277

Chemical Information

目录号 A12500
Mechanism of action Inhibitor
分子量 868.44
化学分子式 C45H50ClN7O7S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1257044-40-8
Synonyms ABT199; ABT 199; GDC-0199; RG7601
SMILES code CC1(CCC(=C(C1)C2=CC=C(C=C2)Cl)CN3CCN(CC3)C4=CC(=C(C=C4)C(=O)NS(=O)(=O)C5=CC(=C(C=C5)NCC6CCOCC6)[N+](=O)[O-])OC7=CN=C8C(=C7)C=CN8)C
化学名称 4-(4-{[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-({3-nitro-4-[(tetrahydro-2H-pyran-4-ylmethyl)amino]phenyl}sulfonyl)-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide

生物活性

Description
ABT-199 is a so-called BH3-mimetic drug, which is designed to block the function of the protein Bcl 2.
Targets
Bcl-2 (Cell-free assay) Bcl-xL (Cell-free assay) Bcl-w (Cell-free assay) Mcl-1 (Cell-free assay)
444 nM(Ki)

溶解性

Solubility (25°C) * In vitro DMSO 100 mg/mL (115.14 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.51 mL 57.57 mL 115.15mL
0.5 mM 2.3 mL 11.51 mL 23.03 mL
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL

*The above data is based on the productmolecular weight 868.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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