ABT-737

目录号: A10255

Bcl-2 Inhibitor

ABT-737

ABT-737 Chemical Structure

CAS NO. 852808-04-9

ABT-737是pan-Bcl-2抑制剂。 IC50值的范围从192 nM(B前细胞系Hal-01)到<10μM(Nalm-6,K562和HL-60)。

库存: 现货

规格 价格 数量
5 mg
¥ 500.00
10 mg
¥ 900.00
50 mg
¥ 3,000.00
100 mg
¥ 4,800.00
10mM * 1mL in DMSO
¥ 800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

ABT-737是pan-Bcl-2抑制剂。 IC50值的范围从192 nM(B前细胞系Hal-01)到<10μM(Nalm-6,K562和HL-60)。
Targets
Target Value
Bcl-2EC50:30.3nM
Bcl-xLEC50:78.7nM
Bcl-wEC50:197.8nM
Bcl-BEC50:1.82 uM
Bfl-1EC50>10 uM
Mcl-1EC50>10 uM
In vitro (25°C) DMSO 100 mg/mL (122.93 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.29 mL 61.47 mL 122.94 mL
0.5 mM 2.46 mL 12.29 mL 24.59 mL
1 mM 1.23 mL 6.15 mL 12.29 mL
5 mM 0.25 mL 1.23 mL 2.46 mL

*The above data is based on the productmolecular weight 813.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A10255
MECHANISM OF ACTION Inhibitor
M. Wt 813.4
Formula C42H45ClN6O5S2
Solubility DMSO>163mg/mL Water<1mg/mL Ethanol<1mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 852808-04-9
Synonyms N/A
SMILES CN(C)CC[C@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]

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