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ABT-737

促销

Bcl-2 抑制剂

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产品目录号: A10255

库存状态:中国现货中国现货

产品名 目录号 价格 数量
ABT-737 5mg A10255-5
¥ 500.00
ABT-737 10mg A10255-10
¥ 900.00
ABT-737 50mg A10255-50
¥ 3,000.00
ABT-737 100mg A10255-100
¥ 4,800.00
ABT-737 10mM * 1mL in DMSO A10255-10mM-D
¥ 800.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).

ABT-737

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 ABT-737 发表的文献 (6)
  • Meikle V, .et al. A protein complex from human milk enhances the activity of antibiotics and drugs against Mycobacterium tuberculosis, Antimicrob Agents Chemother, 2018, Nov 12. pii: AAC.01846-18 PMID: 30420480
  • Chauhan D, .et al. BAX/BAK-Induced Apoptosis Results in Caspase-8-Dependent IL-1汕 Maturation in Macrophages, Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805
  • Jose Mario Gonzalez-Meljem, .et al. Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma, Nat Commun, 2017, 8: 1819 PMID: 29180744
  • Zhang C, .et al. Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1-Parkin pathway and modulate cellular drug response, J Biol Chem, 2017, Sep 8;292(36):15105-15120 PMID: 28673964
  • Eun Young Kim, .et al. ABT-737 Synergizes with Cisplatin Bypassing Aberration of Apoptotic Pathway in Non-small Cell Lung Cancer, Neoplasia, 2017, Apr; 19(4): 354每363 PMID: 28319809
  • Masayoshi Toge, .et al. Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer., Int J Oncol., 2015, Apr;46(4):1844-8 PMID: 25647738

Chemical Information

目录号 A10255
Mechanism of action Inhibitor
分子量 813.4
化学分子式 C42H45ClN6O5S2
Solubility DMSO>163mg/mL Water<1mg/mL Ethanol<1mg/mL
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 852808-04-9
Synonyms N/A
SMILES code CN(C)CC[C@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-]
化学名称 4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamide

生物活性

Description
ABT-737 is a pan-Bcl-2 inhibitor. IC50 values ranged from 192 nM (the pre-B cell line Hal-01) to <10 μM (Nalm-6, K562 and HL-60).
Targets
Target Value
Bcl-2EC50:30.3nM
Bcl-xLEC50:78.7nM
Bcl-wEC50:197.8nM
Bcl-BEC50:1.82 uM
Bfl-1EC50>10 uM
Mcl-1EC50>10 uM

溶解性

Solubility (25°C) * In vitro DMSO 100 mg/mL (122.93 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.29 mL 61.47 mL 122.94mL
0.5 mM 2.46 mL 12.29 mL 24.59 mL
1 mM 1.23 mL 6.15 mL 12.29 mL
5 mM 0.25 mL 1.23 mL 2.46 mL

*The above data is based on the productmolecular weight 813.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10255ABT-737<1 mg/mL163 mg/mL<1 mg/mL
A10022ABT-263 (Navitoclax)<1 mg/mL195 mg/mL<1 mg/mL
A10665Obatoclax mesylate (GX15-070)<1 mg/mL83 mg/mL<1 mg/mL
A10955TW-37<1 mg/mL115 mg/mL4 mg/mL
A10984VX-765<1 mg/mL102 mg/mL102 mg/mL
A11090PAC-1<1 mg/mL78 mg/mL16 mg/mL
A10491JNJ 26854165<1 mg/mL66 mg/mL2 mg/mL
A11931RITA (NSC 652287)<1 mg/mL115 mg/mL4 mg/mL
A10522Lenalidomide (CC-5013)<1 mg/mL52 mg/mL<1 mg/mL
A10743Pomalidomide (CC-4047)<1 mg/mL55 mg/mL<1 mg/mL
A11163AT-406<1 mg/mL112 mg/mL112 mg/mL
A11002YM15589 mg/mL55 mg/mL6 mg/mL
A10935Tipifarnib (Zarnestra)<1 mg/mL83 mg/mL<1 mg/mL
A10657Nutlin-3<1 mg/mL116 mg/mL116 mg/mL

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