AC220 (Quizartinib)

目录号: A10027

FLT3 inhibitor

AC220 (Quizartinib) Chemical Structure

CAS NO. 950769-58-1

AC220(Quizartinib)是一种有效的选择性FLT3抑制剂,对于MC4-11和A375,IC50分别为0.56±0.3 nM和> 10 mM。

库存: 现货

规格 价格 数量
5 mg
¥ 500.00
10 mg
¥ 700.00
50 mg
¥ 1,200.00
200 mg
¥ 3,500.00
10mM * 1mL in DMSO
¥ 1,260.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

AC220(Quizartinib)是一种有效的选择性FLT3抑制剂,对于MC4-11和A375,IC50分别为0.56±0.3 nM和> 10 mM。
Targets
FLT3 (ITD) (MV4-11 cells) FLT3 (WT) (RS4;11 cells)
1.1 nM4.2 nM
In vitro (25°C) DMSO 33.2 mg/mL (59.21 mM)
Water <0.3 mg/mL ( mM)
Ethanol <0.5 mg/mL ( mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.83 mL 89.17 mL 178.35 mL
0.5 mM 3.57 mL 17.83 mL 35.67 mL
1 mM 1.78 mL 8.92 mL 17.83 mL
5 mM 0.36 mL 1.78 mL 3.57 mL

*The above data is based on the productmolecular weight 560.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10027
MECHANISM OF ACTION Inhibitor
M. Wt 560.7
Formula C29H32N6O4S
Solubility DMSO>112mg/mL Water<1mg/mL Ethanol>4mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 950769-58-1
Synonyms N/A
SMILES CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3

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