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AC220 (Quizartinib)

促销

FLT3 抑制剂

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产品目录号: A10027

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AC220 5mg A10027-5
¥ 500.00
AC220 10mg A10027-10
¥ 700.00
AC220 50mg A10027-50
¥ 1,200.00
AC220 200mg A10027-200
¥ 3,500.00
AC220 (Quizartinib) 10mM * 1mL in DMSO A10027-10mM-D
¥ 1,260.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively.

AC220 (Quizartinib)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 AC220 (Quizartinib) 发表的文献 (3)
  • N Naganna, .et al. Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice, EBioMedicine, 2019, Jan 24. pii: S2352-3964(19)30012-X PMID: 30686755
  • Cong Li, .et al. AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia., Mol Cancer Ther., 2015, Feb;14(2):375-83. PMID: 25487917
  • Yaping Zhang, .et al. FLT3 and CDK4/6 inhibitors: Signaling mechanisms and tumor burden in subcutaneous and orthotopic mouse models of acute myeloid leukemia, J Pharmacokinet Pharmacodyn., 2014, 41(6): 675每691. PMID: 25326874

Chemical Information

目录号 A10027
Mechanism of action Inhibitor
分子量 560.7
化学分子式 C29H32N6O4S
Solubility DMSO>112mg/mL Water<1mg/mL Ethanol>4mg/mL
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 950769-58-1
Synonyms N/A
SMILES code CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3
化学名称 1-(5-(tert-Butyl)isoxazol-3-yl)-3-(4-(7-(2-morpholinoethoxy)benzo[d]imidazo[2,1-b]thiazol-2-yl)phenyl)urea

生物活性

Description
AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively.
Targets
FLT3 (ITD) (MV4-11 cells) FLT3 (WT) (RS4;11 cells)
1.1 nM4.2 nM

溶解性

Solubility (25°C) * In vitro DMSO 33.2 mg/mL (59.21 mM)
Water <0.3 mg/mL ( mM)
Ethanol <0.5 mg/mL ( mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.83 mL 89.17 mL 178.35mL
0.5 mM 3.57 mL 17.83 mL 35.67 mL
1 mM 1.78 mL 8.92 mL 17.83 mL
5 mM 0.36 mL 1.78 mL 3.57 mL

*The above data is based on the productmolecular weight 560.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Biological Activity

AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively. AC220 exhibits low nanomolar potency in biochemical and cellular assays and exceptional kinase selectivity, and in animal models is efficacious at doses as low as 1 mg/kg given orally once daily. The data reveal that the combination of excellent potency, selectivity, and pharmacokinetic properties is unique to AC220, which therefore is the first candidate with a profile that matches the characteristics desirable for a clinical FLT3 inhibitor. [1][2]

References on AC220 (Quizartinib)
  • [1] Blood 2009;114: 2984-2992
  • [2] Clin Adv Hematol Oncol. 2010 Jun;;8(6):429-44.
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