ACY-1215 (Rocilinostat)

目录号: A11940

HDAC6 抑制剂

ACY-1215 (Rocilinostat)

ACY-1215 (Rocilinostat) Chemical Structure

CAS NO. 1316214-52-4

ACY-1215 (Rocilinostat)是一种选择性HDAC6抑制剂,从而通过Hsp90的超乙酰化作用破坏Hsp90蛋白伴侣系统,并防止随后的总蛋白降解。

库存: 现货

规格 价格 数量
10 mg
¥ 400.00
50 mg
¥ 800.00
100 mg
¥ 1,250.00
10mM * 1mL in DMSO
¥ 500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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ACY-1215 (Rocilinostat)是一种选择性HDAC6抑制剂,从而通过Hsp90的超乙酰化作用破坏Hsp90蛋白伴侣系统,并防止随后的总蛋白降解。
Targets
Target Value
HDAC6IC50: 4.7nM
HDAC2IC50: 48nM
HDAC3IC50: 51nM
HDAC1IC50: 58nM
HDAC8IC50: 100nM
HDAC7IC50: 1.4μM
HDAC5IC50: 5μM
HDAC4IC50: 7μM
HDAC9IC50: >10μM
HDAC11IC50: >10μM
Sirtuin1IC50: >10μM
Sirtuin2IC50: >10μM
In vitro (25°C) DMSO 86 mg/mL (198.38 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.07 mL 115.34 mL 230.68 mL
0.5 mM 4.61 mL 23.07 mL 46.14 mL
1 mM 2.31 mL 11.53 mL 23.07 mL
5 mM 0.46 mL 2.31 mL 4.61 mL

*The above data is based on the productmolecular weight 433.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11940
作用机制 Inhibitor (抑制剂)
M. Wt 433.5
Formula C24H27N5O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1316214-52-4
Synonyms ACY1215
SMILES C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO

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