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AEE788

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EGFR 抑制剂

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产品目录号: A10043

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AEE788 5mg A10043-5
¥ 900.00
AEE788 10mg A10043-10
¥ 1,600.00
AEE788 25mg A10043-25
¥ 3,200.00
AEE788 50mg A10043-50
¥ 5,500.00
AEE788 10mM * 1mL in DMSO A10043-10mM-D
¥ 1,650.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2.

AEE788

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Chemical Information

目录号 A10043
Mechanism of action Inhibitor
分子量 440.6
化学分子式 C27H32N6
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 497839-62-0
Synonyms AEE-788, NVP-AEE788
SMILES code CCN1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=C(N3)N=CN=C4N[C@H](C)C5=CC=CC=C5
化学名称 6-[4-[(4-Ethylpiperazin-1-yl)methyl]phenyl]-N-[(1R)-1-phenylethyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

生物活性

Description
AEE788 is an orally bioavailable multiple-receptor tyrosine kinase inhibitor that inhibits phosphorylation of the tyrosine kinases of EGFR, HER2 and VEGF2.
Targets
Target Value
EGFRIC50: 2nM
HER2/ErbB2IC50: 6nM
c-AblIC50: 52nM
FLT1IC50: 59nM
c-FmsIC50: 60nM
c-SrcIC50: 61nM
KDRIC50: 77nM
HER4/ErbB4IC50: 160nM
PDGFRβIC50: 320nM
FLT4IC50: 330nM
FLT3IC50: 730nM
RETIC50: 740nM
c-KitIC50: 790nM
TekIC50: 2.1μM
C-Raf-1IC50: 2.8μM
c-MetIC50: 2.9μM
CDK1/CyclinBIC50: 8.0μM
IGF-1RIC50: >10μM
Insulin ReceptorIC50: >10μM
PKCαIC50: >10μM
PKAIC50: >10μM

溶解性

Solubility (25°C) * In vitro DMSO 88 mg/mL (199.73 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.7 mL 113.48 mL 226.96mL
0.5 mM 4.54 mL 22.7 mL 45.39 mL
1 mM 2.27 mL 11.35 mL 22.7 mL
5 mM 0.45 mL 2.27 mL 4.54 mL

*The above data is based on the productmolecular weight 440.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Cat. No.

Product NameSolubility(mg/mL)
WaterDMSOEthanol
A10043 AEE788 <1 mg/mL 88 mg/mL <1 mg/mL
A11022 AG-1478 (Tyrphostin AG-1478) <1 mg/mL 25 mg/mL 13 mg/mL
A10047 AG 490 <1 mg/mL 59 mg/mL 6 mg/mL
A11027 ARRY-380 <1 mg/mL 114 mg/mL <1 mg/mL
A11158 ARRY334543 <1 mg/mL 6 mg/mL <1 mg/mL
A11155 AST-1306 <1 mg/mL 124 mg/mL <1 mg/mL
A10116 AZD8931 <1 mg/mL 40 mg/mL <1 mg/mL
A11334 BIBX 1382 50 mg/mL 50 mg/mL N/A
A11209 Lenalidomide (CC-5013) <1 mg/mL 113 mg/mL 20 mg/mL
A10743 BMS 599626 (AC480) <1 mg/mL 55 mg/mL <1 mg/mL
A10211 Canertinib (CI-1033) <1 mg/mL 2 mg/mL 9 mg/mL
A10210 Chrysophanic acid (Chrysophanol) <1 mg/mL <1 mg/mL <1 mg/mL
A10242 CP-724714 <1 mg/mL 94 mg/mL 94 mg/mL
A10362 Erlotinib hydrochloride <1 mg/mL 3 mg/mL <1 mg/mL
A10422 Gefitinib (Iressa) <1 mg/mL 89 mg/mL 4 mg/mL
A10514 Lapatinib Ditosylate <1 mg/mL 185 mg/mL <1 mg/mL
A10612 Mubritinib (TAK 165) 13 mg/mL <1 mg/mL <1 mg/mL
A10638 Neratinib (HKI-272) 2 mg/mL <1 mg/mL <1 mg/mL
A10678 OSI-420 83 mg/mL 2 mg/mL <1 mg/mL
A10702 PD153035 (HCl salt) <1 mg/mL <1 mg/mL <1 mg/mL
A10706 Pelitinib (EKB-569) <1 mg/mL 13 mg/mL <1 mg/mL
A11051 PF299804 <1 mg/mL 19 mg/mL <1 mg/mL
A11236 TAK-285 <1 mg/mL 110 mg/mL 54 mg/mL
A10053 Tyrphostin AG 879 36 mg/mLtd <1 mg/mL 3 mg/mL
A10990 WZ3146 <1 mg/mL 93 mg/mL <1 mg/mL
A10991 WZ4002 13 mg/mL <1 mg/mL <1 mg/mL
A10992 WZ8040 96 mg/mL <1 mg/mL 3 mg/mL

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