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AF-353

P2X3/P2X2/3 receptor 拮抗剂

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产品目录号: A13131

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AF-353 5mg A13131-5
¥ 900.00
AF-353 10mg A13131-10
¥ 1,600.00
AF-353 25mg A13131-25
¥ 3,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).

AF-353

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Chemical Information

目录号 A13131
Mechanism of action Antagonist
分子量 400.21
化学分子式 C14H17IN4O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 865305-30-2
Synonyms AF353, AF 353
SMILES code CC(C)C1=CC(=C(C=C1OC2=CN=C(N=C2N)N)I)OC
化学名称 5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine

生物活性

Description
AF-353 is a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist, inhibits human and rat P2X3 (pIC50= 8.0).

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.99 mL 124.93 mL 249.87mL
0.5 mM 5 mL 24.99 mL 49.97 mL
1 mM 2.5 mL 12.49 mL 24.99 mL
5 mM 0.5 mL 2.5 mL 5 mL

*The above data is based on the productmolecular weight 400.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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