Afuresertib HCl

目录号: A13030

AKT inhibitor‎

Afuresertib HCl

Afuresertib HCl Chemical Structure

CAS NO. 1047645-82-8

Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

库存: 现货

规格 价格 数量
5 mg
¥ 1,000.00
10 mg
¥ 1,500.00
25 mg
¥ 2,400.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.56 mL 107.81 mL 215.62 mL
0.5 mM 4.31 mL 21.56 mL 43.12 mL
1 mM 2.16 mL 10.78 mL 21.56 mL
5 mM 0.43 mL 2.16 mL 4.31 mL

*The above data is based on the productmolecular weight 463.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13030
MECHANISM OF ACTION Inhibitor
M. Wt 463.78
Formula C18H18Cl3FN4OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1047645-82-8
Synonyms GSK2110183, GSK 2110183
SMILES CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl.Cl

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