Trusted by 10,000+ Scientists since 2006
微信关注
申请试用装

Afuresertib HCl

促销

AKT 抑制剂?€?

0 Customer Reviews
产品目录号: A13030

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Afuresertib HCl 5mg A13030-5
¥ 1,000.00
Afuresertib HCl 10mg A13030-10
¥ 1,500.00
Afuresertib HCl 25mg A13030-25
¥ 2,400.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Afuresertib HCl

双击上述图片即可查看完整大小

缩小
放大

更多视图

顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A13030
Mechanism of action Inhibitor
分子量 463.78
化学分子式 C18H18Cl3FN4OS
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1047645-82-8
Synonyms GSK2110183, GSK 2110183
SMILES code CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl.Cl
化学名称 N-((S)-1-amino-3-(3-fluorophenyl)propan-2-yl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)thiophene-2-carboxamide hydrochloride

生物活性

Description
Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.56 mL 107.81 mL 215.62mL
0.5 mM 4.31 mL 21.56 mL 43.12 mL
1 mM 2.16 mL 10.78 mL 21.56 mL
5 mM 0.43 mL 2.16 mL 4.31 mL

*The above data is based on the productmolecular weight 463.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Ordering online

To place an order online, simply browse to the product you are interested in and click on the 'Add to Cart' button. To complete this process, you will need to confirm the size and quantity of the products that you require.

To complete an order you will need to register using our simple online registration process. We do not share your contact details with any third parties.

When you are ready to check out simply enter your PO number to complete the ordering process. Please ensure that you send us a copy of your PO by fax or email afterwards.  We will then liaise with you or your purchasing department to confirm the order.

Found your products but not ready to order?

Why not use our WishList feature to store lists of products? This convenient feature allows you to manage lists, append notes to products and share lists with co-workers or colleagues.

Ordering offline

You can email or fax us your purchase order and we will place the order for you. You can also phone us to place the order.  Our contact details are:

We require the following information to process your order:
  • The catalog number for each product. 
  • Your email address or fax number. 
  • Your name and telephone number. 
  • Shipping address and billing address.
  • Purchase order numbers.

产品标签

使用空格分隔标签。使用单引号(')标注词组。

Similar product(s)


Keywords:购买 Afuresertib HCl | Afuresertib HCl 供应商 | 订购 Afuresertib HCl | Afuresertib HCl 价格 | Afuresertib HCl 生产商 | 订单 Afuresertib HCl | Afuresertib HCl 代理商 | 购买 1047645-82-8| 1047645-82-8 供应商 | 订购 1047645-82-8 | 1047645-82-8 价格 | 1047645-82-8 生产商 | 订单 1047645-82-8 | 1047645-82-8 代理商|buy Afuresertib HCl | Afuresertib HCl Supplier | purchase Afuresertib HCl | Afuresertib HCl cost | Afuresertib HCl manufacturer | order Afuresertib HCl | Afuresertib HCl distributor | buy 1047645-82-8| 1047645-82-8 Supplier | purchase 1047645-82-8 | 1047645-82-8 cost | 1047645-82-8 manufacturer | order 1047645-82-8 | 1047645-82-8 distributor