Afuresertib HCl

Name: Afuresertib HCl
SKU: A13030
Price: 245 CNY
Rating: 5 (288 reviews)

目录号: A13030

AKT 抑制剂

Afuresertib，也被称为 GSK2110183，是一种口服生物可用的 丝氨酸/苏氨酸蛋白激酶Akt（蛋白激酶B） 抑制剂，具有潜在的抗肿瘤活性。它结合并抑制Akt的活性，这可能导致抑制 PI3K/Akt信号通路 和肿瘤细胞增殖，以及诱导肿瘤细胞凋亡。 PI3K/Akt信号通路 的激活经常与肿瘤生成相关，而失调的 PI3K/Akt信号 可能导致肿瘤对多种抗肿瘤药物的抗药性。

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Grouped product items
规格	价格	库存
2mg	¥245.00	现货
5mg	¥420.00	现货
10mg	¥630.00	现货
25mg	¥1,120.00	现货
50mg	¥1,820.00	现货
100mg	¥3,185.00	现货
200mg	¥4,130.00	现货
*10mM 1mL in DMSO**	¥490.00	现货
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Data Sheet

SDS

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生物活性

Discription

Afuresertib, also known as GSK2110183, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. It binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Targets

Target	Value

产品信息

目录号	A13030
分子式	C18H18Cl3FN4OS
分子量	463.78
CAS号	1047645-82-8
SMILES	CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl.Cl
其他名称	GSK2110183, GSK 2110183
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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