Afuresertib

Name: Afuresertib
SKU: A16392
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A16392

Akt 抑制剂

Afuresertib 是一种效力强大的口服生物利用度 Akt 抑制剂，其 Ki 分别为 Akt1 0.08 nM、Akt2 2 nM 和 Akt3 2.6 nM。目前处于 第二阶段 临床试验。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥280.00	现货
5mg	¥455.00	现货
10mg	¥630.00	现货
25mg	¥1,190.00	现货
50mg	¥1,960.00	现货
100mg	¥3,465.00	现货
500mg	¥7,595.00	现货
*10mM 1mL in DMSO**	¥455.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

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生物活性

Discription

Afuresertib is a potent, orally bioavailable Akt inhibitor with Ki of 0.08 nM, 2 nM, and 2.6 nM for Akt1, Akt2, and Akt3, respectively. Phase 2.

Targets

Target	Value

产品信息

目录号	A16392
分子式	C18H17Cl2FN4OS
分子量	427.32
CAS号	1047644-62-1
SMILES	CN1C(=C(C=N1)Cl)C2=C(SC(=C2)C(=O)NC(CC3=CC(=CC=C3)F)CN)Cl
其他名称	GSK 2110183, GSK2110183, GSK-2110183
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	79 mg/mL (184.87 mM)
	Water	Insoluble
	Ethanol	79 mg/mL (184.87 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.4 mL	117.01 mL	234.02 mL
0.5 mM	4.68 mL	23.4 mL	46.8 mL
1 mM	2.34 mL	11.7 mL	23.4 mL
5 mM	0.47 mL	2.34 mL	4.68 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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