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AG-1024 (Tyrphostin)

促销

IGF-1R 抑制剂

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产品目录号: A11400

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AG-1024 (Tyrphostin) 5mg A11400-5
¥ 600.00
AG-1024 (Tyrphostin) 10mg A11400-10
¥ 1,100.00
AG-1024 (Tyrphostin) 25mg A11400-25
¥ 2,200.00
AG-1024 (Tyrphostin) 50mg A11400-50
¥ 3,500.00
AG-1024 (Tyrphostin) 10mM * 1mL in DMSO A11400-10mM-D
¥ 700.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AG-1024 (Tyrphostin) is a specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.

AG-1024 (Tyrphostin)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 AG-1024 (Tyrphostin) 发表的文献 (1)
  • Maeda A, .et al. Safranal, a novel protein tyrosine phosphatase 1B inhibitor, activates insulin signaling in C2C12 myotubes and improves glucose tolerance in diabetic KK-Ay mice., Mol Nutr Food Res. , 2014, 58(6):1177-89 PMID: 24668740

Chemical Information

目录号 A11400
Mechanism of action Inhibitor
分子量 305.2
化学分子式 C14H13BrN2O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 65678-07-1
Synonyms AG1024
SMILES code CC(C)(C)C1=C(C(=CC(=C1)C=C(C#N)C#N)Br)O
化学名称 [3-bromo-5-(1,1-dimethylethyl)-4-hydroxyphenyl]methylene

生物活性

Description
AG-1024 (Tyrphostin) is a specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor tyrosine kinase activity. Exhibits lower IC50 values for IGF-1 than for the insulin receptor. Also inhibits insulin-stimulated cellular proliferation.
Targets
IGF-1R Insulin Receptor
7 μM57 μM

溶解性

Solubility (25°C) * In vitro DMSO 61 mg/mL (199.88 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.77 mL 163.83 mL 327.65mL
0.5 mM 6.55 mL 32.77 mL 65.53 mL
1 mM 3.28 mL 16.38 mL 32.77 mL
5 mM 0.66 mL 3.28 mL 6.55 mL

*The above data is based on the productmolecular weight 305.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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