AG-490

目录号: A10047

EGFR 抑制剂

AG-490 Chemical Structure

CAS NO. 133550-30-8

AG 490是EGF受体酪氨酸激酶的选择性抑制剂 (EGFR和ErbB2的IC50值分别为2和13.5μM)。也抑制对Lck,Lyn,Btk,Syk和Src无活性的JAK2。

库存: 现货

规格 价格 数量
10 mg
¥ 300.00
50 mg
¥ 800.00
100 mg
¥ 1,100.00
200 mg
¥ 2,000.00
10mM * 1mL in DMSO
¥ 680.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

AG 490是EGF受体酪氨酸激酶的选择性抑制剂 (EGFR和ErbB2的IC50值分别为2和13.5μM)。也抑制对Lck,Lyn,Btk,Syk和Src无活性的JAK2。
靶点信息
EGFR (Cell-free assay) JAK2 (Cell-free assay) ErbB2 (Cell-free assay)
0.1 μM~10 μM13.5 μM
In vitro (25°C) DMSO 59 mg/mL (200.47 mM)
Water <1 mg/mL (<1 mM)
Ethanol 6 mg/mL (20.38 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.98 mL 169.89 mL 339.79 mL
0.5 mM 6.8 mL 33.98 mL 67.96 mL
1 mM 3.4 mL 16.99 mL 33.98 mL
5 mM 0.68 mL 3.4 mL 6.8 mL

*The above data is based on the productmolecular weight 294.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10047
MECHANISM OF ACTION Inhibitor
M. Wt 294.3
Formula C17H14N2O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 133550-30-8
Synonyms Tyrphostin AG490
SMILES C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N

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