AGI-5198 (IDH-C35)

Name: AGI-5198 (IDH-C35)
SKU: A12902

目录号: A12902

IDH1 抑制剂

AGI-5198 (IDH-C35) Chemical Structure

CAS NO. 1355326-35-0

AGI-5198 (IDH-C35)是一种非常有效的选择性IDH1突变抑制剂，具有潜在的抗癌活性。

库存：现货

规格	价格	数量
10 mg	￥ 460.00
25 mg	￥ 810.00
50 mg	￥ 1,350.00
10mM * 1mL in DMSO	￥ 1,700.00

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产品详情

生物活性

AGI-5198 (IDH-C35)是一种非常有效的选择性IDH1突变抑制剂，具有潜在的抗癌活性。

靶点信息

R132H-IDH1	R132C-IDH1
70 nM	0.16 μM

溶解度 *

In vitro (25°C)	DMSO	22 mg/mL (47.56 mM)
	Water	Insoluble
	Ethanol	13 mg/mL (28.1 mM)
In vivo	0.5% methylcellulose+0.2% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.62 mL	108.09 mL	216.19 mL
0.5 mM	4.32 mL	21.62 mL	43.24 mL
1 mM	2.16 mL	10.81 mL	21.62 mL
5 mM	0.43 mL	2.16 mL	4.32 mL

*The above data is based on the productmolecular weight 462.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12902
作用机制	Inhibitor (抑制剂)
M. Wt	462.56
Formula	C27H31FN4O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1355326-35-0
Synonyms	AGI5198,AGI 5198, IDHC35
SMILES	CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C