AGI-5198 (IDH-C35)

目录号: A12902

IDH1 inhibitor

AGI-5198 (IDH-C35) Chemical Structure

CAS NO. 1355326-35-0

AGI-5198, also know as IDH-C35, is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity.

库存: 现货

规格 价格 数量
5 mg
¥ 700.00
10 mg
¥ 1,100.00
25 mg
¥ 1,800.00
50 mg
¥ 2,100.00
10mM * 1mL in DMSO
¥ 1,700.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

AGI-5198, also know as IDH-C35, is the a very potent and selective mutant IDH1 inhibitor that was shown to potential anticancer activity.
Targets
R132H-IDH1 R132C-IDH1
70 nM0.16 μM
In vitro (25°C) DMSO 24 mg/mL (51.88 mM)
Water <1 mg/mL (<1 mM)
Ethanol 14 mg/mL (30.26 mM)
In vivo 0.5% methylcellulose/0.2% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.62 mL 108.09 mL 216.19 mL
0.5 mM 4.32 mL 21.62 mL 43.24 mL
1 mM 2.16 mL 10.81 mL 21.62 mL
5 mM 0.43 mL 2.16 mL 4.32 mL

*The above data is based on the productmolecular weight 462.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A12902
MECHANISM OF ACTION Inhibitor
M. Wt 462.56
Formula C27H31FN4O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1355326-35-0
Synonyms AGI5198,AGI 5198, IDHC35
SMILES CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C

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