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AGN 205728 is a potent and selective RARγ antagonist with Ki/IC95 values of 3 nM/ 0.6 nM; no inhibiton on RARα and RARβ.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.86 mL | 114.28 mL | 228.56 mL |
| 0.5 mM | 4.57 mL | 22.86 mL | 45.71 mL |
| 1 mM | 2.29 mL | 11.43 mL | 22.86 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.57 mL |
*The above data is based on the productmolecular weight 437.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16296 |
|---|---|
| MECHANISM OF ACTION | Antagonist |
| M. Wt | 437.53 |
| Formula | C29H27NO3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 859498-05-8 |
| Synonyms | AGN205728, AGN-205728 |
| SMILES | CC1=CC=C(C=C1)C2=CCC(C)(C)C3=C2C=CC(=C3)/C(=N/O)/C=C/C4=CC=C(C=C4)C(=O)O |
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