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Altiratinib (DCC2701)是一种新型的c-MET/TIE-2/VEGFR抑制剂；与体外HGF拮抗剂相比，可有效降低体内的肿瘤负荷并阻断c-MET pTyr（1349）介导的信号传导，细胞生长和迁移。
| In vitro | DMSO | 99 mg/mL (193.94 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.59 mL | 97.95 mL | 195.9 mL |
| 0.5 mM | 3.92 mL | 19.59 mL | 39.18 mL |
| 1 mM | 1.96 mL | 9.8 mL | 19.59 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.92 mL |
*The above data is based on the productmolecular weight 510.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14387 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 510.46 |
| Formula | C26H21F3N4O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1345847-93-9 |
| Synonyms | DCC-2701, DCC2701, DCC 2701, DP 5164, DP5164, DP-5164 |
| SMILES | FC1=CC=C(NC(C2(C(NC3=C(F)C=C(OC4=CC(/N=C(O)/C5CC5)=NC=C4)C(F)=C3)=O)CC2)=O)C=C1 |
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