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neutrophil elastase 抑制剂

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产品目录号: A12779


产品名 目录号 价格 数量
Alvelestat 5mg A12779-5
¥ 1,200.00
Alvelestat 10mg A12779-10
¥ 1,900.00
Alvelestat 25mg A12779-25
¥ 3,500.00
Alvelestat 10mM * 1mL in DMSO A12779-10mM-D
¥ 2,230.00



Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE).





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A12779
Mechanism of action Inhibitor
分子量 545.5
化学分子式 C25H22F3N5O4S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 848141-11-7
Synonyms AZD9668,AZD 9668,AZD-9668
SMILES code CC1=C(C=C(C(=O)N1C2=CC=CC(=C2)C(F)(F)F)C(=O)NCC3=NC=C(C=C3)S(=O)(=O)C)C4=CC=NN4C
化学名称 6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-((5-(methylsulfonyl)pyridin-2-yl)methyl)-2-oxo-1-(3-(trifluoromethyl)phenyl)-1,2-dihydropyridine-3-carboxamide


Avelestat, also known as AZD9668, is a novel, oral inhibitor of neutrophil elastase (NE).
neutrophil elastase neutrophil elastase
9.4 nM(Ki)12 nM


Solubility (25°C)* In vitro DMSO 100 mg/mL (183.3 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.33 mL 91.66 mL 183.32mL
0.5 mM 3.67 mL 18.33 mL 36.66 mL
1 mM 1.83 mL 9.17 mL 18.33 mL
5 mM 0.37 mL 1.83 mL 3.67 mL

*The above data is based on the productmolecular weight 545.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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