AM 114

目录号: A14922

20S proteasome inhibitor

AM 114

AM 114 Chemical Structure

CAS NO. 856849-35-9

AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins.

库存: 现货

规格 价格 数量
10 mg
¥ 600.00
25 mg
¥ 1,200.00
50 mg
¥ 2,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

AM 114, a derivative of boronic chalcone, is a potent small-molecule inhibitor of the proteasome that inhibits the chymotrypsin-like activity of the 20S proteasome, with a value of 50% inhibition concentration IC50 of approximately 1 uM, resulting in a significant accumulation of ubiquitinated p53 and other cellular proteins in whole cells without significantly disrupting the interaction of p53 and murine double minute 2 (mdm2) proteins.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.52 mL 132.62 mL 265.24 mL
0.5 mM 5.3 mL 26.52 mL 53.05 mL
1 mM 2.65 mL 13.26 mL 26.52 mL
5 mM 0.53 mL 2.65 mL 5.3 mL

*The above data is based on the productmolecular weight 377.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A14922
MECHANISM OF ACTION Inhibitor
M. Wt 377.01
Formula C20H21B2NO5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 856849-35-9
Synonyms N/A
SMILES B(C1=CC=C(C=C1)C=C2CN(CC(=CC3=CC=C(C=C3)B(O)O)C2=O)C)(O)O

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