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AM095 is a potent LPA1 receptor antagonist because it inhibited GTP??S binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0.98 and 0.73 μM, respectively, and exhibited no LPA1 agonism.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.9 mL | 104.5 mL | 209 mL |
| 0.5 mM | 4.18 mL | 20.9 mL | 41.8 mL |
| 1 mM | 2.09 mL | 10.45 mL | 20.9 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
*The above data is based on the productmolecular weight 478.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13981 |
|---|---|
| MECHANISM OF ACTION | Antagonist |
| M. Wt | 478.47 |
| Formula | C27H23N2NaO5 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1345614-59-6 |
| Synonyms | AM 095, AM-095 |
| SMILES | CC1=NOC(=C1NC(=O)O[C@H](C)C2=CC=CC=C2)C3=CC=C(C=C3)C4=CC=C(C=C4)CC(=O)[O-].[Na+] |
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