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Ambrisentan (BSF 208075)


EndothelinA receptor 拮抗剂

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产品目录号: A11291


产品名 目录号 价格 数量
Ambrisentan 5mg A11291-5
¥ 500.00
Ambrisentan 10mg A11291-10
¥ 600.00
Ambrisentan 25mg A11291-25
¥ 1,100.00
Ambrisentan 50mg A11291-50
¥ 1,900.00
Ambrisentan (BSF 208075) 10mM * 1mL in DMSO A11291-10mM-D
¥ 500.00



Ambrisentan functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA).

Ambrisentan (BSF 208075)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Ambrisentan (BSF 208075) 发表的文献 (2)
  • Tony Ngo, .et al. Orphan receptor ligand discovery by pickpocketing pharmacological neighbors, Nat Chem Biol, 2017, Feb; 13(2): 235每242 PMID: 27992882
  • Toshiaki Okamoto, .et al. Antifibrotic effects of ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model, World J Hepatol, 2016, Aug 8; 8(22): 933每941 PMID: 27574547

Chemical Information

目录号 A11291
Mechanism of action Antagonist
分子量 378.4
化学分子式 C22H22N2O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 177036-94-1
Synonyms BSF 208075,
SMILES code CC1=CC(=NC(=N1)O[C@H](C(=O)O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)C
化学名称 (2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy- 3,3-diphenylpropanoic acid


Ambrisentan functions as an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA).


Solubility (25°C)* In vitro DMSO 76 mg/mL (200.83 mM)
Water <1 mg/mL (<1 mM)
Ethanol 22 mg/mL (58.13 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.43 mL 132.14 mL 264.27mL
0.5 mM 5.29 mL 26.43 mL 52.85 mL
1 mM 2.64 mL 13.21 mL 26.43 mL
5 mM 0.53 mL 2.64 mL 5.29 mL

*The above data is based on the productmolecular weight 378.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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