AMG-073 HCl (Cinacalcet HCl)

目录号: A10219

CaSR activator

AMG-073 HCl (Cinacalcet HCl)

AMG-073 HCl (Cinacalcet HCl) Chemical Structure

CAS NO. 364782-34-3

AMG-073 HCl(Cinacalcet HCl)是一种用于治疗甲状旁腺功能亢进的化合物,称为拟钙剂,通过增加甲状旁腺钙敏感受体(CaR)对细胞外钙的敏感性来减少甲状旁腺激素(PTH)的合成和分泌 。

库存: 现货

规格 价格 数量
10 mg
¥ 400.00
50 mg
¥ 1,000.00
100 mg
¥ 1,800.00
10mM * 1mL in DMSO
¥ 800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

AMG-073 HCl(Cinacalcet HCl)是一种用于治疗甲状旁腺功能亢进的化合物,称为拟钙剂,通过增加甲状旁腺钙敏感受体(CaR)对细胞外钙的敏感性来减少甲状旁腺激素(PTH)的合成和分泌 。
靶点信息
CaSR
2.8 μM
In vitro (25°C) DMSO 79 mg/mL (200.57 mM)
Water <1 mg/mL (<1 mM)
Ethanol 33 mg/mL (83.78 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.39 mL 126.94 mL 253.87 mL
0.5 mM 5.08 mL 25.39 mL 50.77 mL
1 mM 2.54 mL 12.69 mL 25.39 mL
5 mM 0.51 mL 2.54 mL 5.08 mL

*The above data is based on the productmolecular weight 393.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10219
作用机制 Activator (激活剂)
M. Wt 393.9
Formula C22H23ClF3N
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 364782-34-3
Synonyms Mimpara, Sensipar
SMILES C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl

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