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AMG 208

c-Met 抑制剂

158 Customer Reviews
产品目录号: A10063

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AMG 208 5mg A10063-5
¥ 900.00
AMG 208 10mg A10063-10
¥ 1,600.00
AMG 208 50mg A10063-50
¥ 5,500.00
AMG 208 100mg A10063-100
¥ 7,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AMG 208 is a novel c-Met inhibitor that inhibits the ligand-dependent and ligand-independent activation of c-Met, inhibiting its tyrosine kinase activity.

AMG 208

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Chemical Information

目录号 A10063
Mechanism of action Inhibitor
分子量 383.4
化学分子式 C22H17N5O2
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1002304-34-8
Synonyms AMG208, AMG-208
SMILES code COC1=CC2=NC=CC(=C2C=C1)OCC3=NN=C4N3N=C(C=C4)C5=CC=CC=C5
化学名称 7-Methoxy-4-[(6-phenyl-1,2,4-triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline

生物活性

Description
AMG 208 is a novel c-Met inhibitor that inhibits the ligand-dependent and ligand-independent activation of c-Met, inhibiting its tyrosine kinase activity.
Targets
c-Met
9 nM

溶解性

Solubility (25°C) * In vitro DMSO 0.25 mg/mL (<1 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.08 mL 130.41 mL 260.82mL
0.5 mM 5.22 mL 26.08 mL 52.16 mL
1 mM 2.61 mL 13.04 mL 26.08 mL
5 mM 0.52 mL 2.61 mL 5.22 mL

*The above data is based on the productmolecular weight 383.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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