AMG-458

目录号: A11055

c-Met inhibitor

AMG-458

AMG-458 Chemical Structure

CAS NO. 913376-83-7

AMG-458 is a potent inhibitor of c-Met with an IC50 value of 60nM and displays selectivity against VEGFR2.

库存: 现货

规格 价格 数量
5 mg
¥ 1,500.00
10 mg
¥ 2,100.00
50 mg
¥ 6,200.00
100 mg
¥ 10,000.00
10mM * 1mL in DMSO
¥ 2,210.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

AMG-458 is a potent inhibitor of c-Met with an IC50 value of 60nM and displays selectivity against VEGFR2.
Targets
Target Value
c-Met(H1094R)ki: 0.5nM
c-Met(V1092I)ki: 1.1nM
c-Met(Human)ki: 1.2nM
c-Met(Mouse)ki: 2.0nM
c-Met(D1228H)ki: 2.2nM
c-Met(M1250T)ki: 4.1nM
c-Met(Y1230H)ki: 4.5nM
VEGFR2ki: 4.1μM
In vitro (25°C) DMSO 21 mg/mL (38.91 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol/citrate vehicle 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.53 mL 92.66 mL 185.32 mL
0.5 mM 3.71 mL 18.53 mL 37.06 mL
1 mM 1.85 mL 9.27 mL 18.53 mL
5 mM 0.37 mL 1.85 mL 3.71 mL

*The above data is based on the productmolecular weight 539.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A11055
MECHANISM OF ACTION Inhibitor
M. Wt 539.6
Formula C30H29N5O5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 913376-83-7
Synonyms AMG458, AMG 458
SMILES CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=NC=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC

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