AMG 900

目录号: A11066

Aurora Kinase inhibitor

AMG 900 Chemical Structure

CAS NO. 945595-80-2

AMG 900 is a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.

库存: 现货

规格 价格 数量
5 mg
¥ 900.00
10 mg
¥ 1,600.00
50 mg
¥ 4,500.00
100 mg
¥ 7,500.00
10mM * 1mL in DMSO
¥ 1,500.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

AMG 900 is a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines.
Targets
Target Value
AuroraCIC50: 1nM
AuroraBIC50: 4nM
AuroraAIC50: 5nM
p38αIC50: 53nM
TYK2IC50: 220nM
JNK2IC50: 520nM
MetIC50: 550nM
Tie-2IC50: 650nM
In vitro (25°C) DMSO 100 mg/mL (198.57 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.86 mL 99.29 mL 198.57 mL
0.5 mM 3.97 mL 19.86 mL 39.71 mL
1 mM 1.99 mL 9.93 mL 19.86 mL
5 mM 0.4 mL 1.99 mL 3.97 mL

*The above data is based on the productmolecular weight 503.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11066
MECHANISM OF ACTION Inhibitor
M. Wt 503.6
Formula C28H21N7OS
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 945595-80-2
Synonyms AMG-900, AMG900
SMILES CC1=CSC(=C1)C2=NN=C(C3=CC=CC=C32)NC4=CC=C(C=C4)OC5=C(C=CC=N5)C6=NC(=NC=C6)N

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