Amivantamab (JNJ-61186372) is a bispecific human antibody targeting EGFR and MET receptors, designed for its potent anticancer immune activity. This therapeutic antibody functions by inhibiting ligand binding, thereby promoting the endocytosis and subsequent degradation of receptor-antibody complexes. Furthermore, Amivantamab facilitates Fc-dependent cytokinesis in macrophages and enhances antibody-dependent cellular cytotoxicity in natural killer cells, making it a valuable tool in cancer immunotherapy research.
Amivantamab (JNJ-61186372) is a bispecific human antibody targeting EGFR and MET receptors, designed for its potent anticancer immune activity. This therapeutic antibody functions by inhibiting ligand binding, thereby promoting the endocytosis and subsequent degradation of receptor-antibody complexes. Furthermore, Amivantamab facilitates Fc-dependent cytokinesis in macrophages and enhances antibody-dependent cellular cytotoxicity in natural killer cells, making it a valuable tool in cancer immunotherapy research.
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