Amlodipine besylate (Norvasc)

Name: Amlodipine besylate (Norvasc)
SKU: A10069

目录号: A10069

L-type calcium channel blocker

Amlodipine besylate (Norvasc) Chemical Structure

CAS NO. 111470-99-6

Amlodipine besylate是一种L型钙通道阻滞剂，具有降压作用。它抑制去极化大鼠主动脉中Ca2 +诱导的收缩（IC50 = 1.9 nM）。

库存：现货

规格	价格	数量
500 mg	￥ 450.00
10mM * 1mL in DMSO	￥ 640.00

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生物活性

Amlodipine besylate是一种L型钙通道阻滞剂，具有降压作用。它抑制去极化大鼠主动脉中Ca2 +诱导的收缩（IC50 = 1.9 nM）。

溶解度 *

In vitro (25°C)	DMSO	102 mg/mL (179.87 mM)
	Water	Insoluble
	Ethanol	13 mg/mL (22.92 mM)
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.63 mL	88.17 mL	176.34 mL
0.5 mM	3.53 mL	17.63 mL	35.27 mL
1 mM	1.76 mL	8.82 mL	17.63 mL
5 mM	0.35 mL	1.76 mL	3.53 mL

*The above data is based on the productmolecular weight 567.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10069
作用机制	Blocker (阻断剂)
M. Wt	567.1
Formula	C20H25ClN2O5.C6H6O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	111470-99-6
Synonyms	Istin, Norvasc
SMILES	CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O