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Amphotericin B是来自链霉菌属的多烯抗真菌抗生素。Amphotericin B诱导K+泄漏，这与其致死作用是分开的，正如在人类红细胞中所证明的，这是由于对Na+/K+泵的抑制作用所致。
靶点信息
| ergosterol | ||||
| In vitro | DMSO | 20 mg/mL (21.64 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 10.82 mL | 54.11 mL | 108.21 mL |
| 0.5 mM | 2.16 mL | 10.82 mL | 21.64 mL |
| 1 mM | 1.08 mL | 5.41 mL | 10.82 mL |
| 5 mM | 0.22 mL | 1.08 mL | 2.16 mL |
*The above data is based on the productmolecular weight 924.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10073 |
|---|---|
| M. Wt | 924.1 |
| Formula | C47H73NO17 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1397-89-3 |
| Synonyms | Fungilin, Fungizone, AmBisome, Fungisome, Amphocil, Amphotec |
| SMILES | C[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@@H](C[C@H]2[C@@H]([C@H](C[C@](O2)(C[C@H](C[C@H]([C@@H](CC[C@H](C[C@H](CC(=O)O[C@H]([C@@H]([C@@H]1O)C)C)O)O)O)O)O)O)O)C(=O)O)O[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)O)N)O |
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