Anbenitamab (KN-026) is a bispecific antibody engineered to target extracellular domains II and IV of human HER2, effectively blocking both ligand-dependent and ligand-independent signaling pathways associated with this receptor. The inclusion of the IgG1 Fc fragment enhances its interaction with FcR??IIIa, facilitating robust antibody-dependent cell-mediated cytotoxicity (ADCC) and effectively inhibiting tumor cell proliferation. This antibody is primarily researched for its therapeutic potential in HER2-positive metastatic breast cancer (MBC).
Anbenitamab (KN-026) is a bispecific antibody engineered to target extracellular domains II and IV of human HER2, effectively blocking both ligand-dependent and ligand-independent signaling pathways associated with this receptor. The inclusion of the IgG1 Fc fragment enhances its interaction with FcR??IIIa, facilitating robust antibody-dependent cell-mediated cytotoxicity (ADCC) and effectively inhibiting tumor cell proliferation. This antibody is primarily researched for its therapeutic potential in HER2-positive metastatic breast cancer (MBC).
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