Folitixorin (ANX-510)

Name: Folitixorin (ANX-510)
SKU: A12370
Price: 1225 CNY
Rating: 5 (1 reviews)

目录号: A12370

1 篇发表文献

ANX-510 是一种基于叶酸的生物调节剂，具有潜在的抗肿瘤活性。5,10-亚甲基四氢叶酸（MTHF）稳定了氟尿嘧啶代谢物 5-5-氟-2'-脱氧尿苷-5'-O-单磷酸（FdUMP）与其靶酶 胸苷酸合成酶 的共价结合，从而抑制胸苷酸合成酶，耗尽 胸苷三磷酸（TTP），DNA 必需成分，导致肿瘤细胞死亡。与亚叶酸钙不同，MTHF 作为叶酸的活性形式，不需要代谢激活，可能会增强氟尿嘧啶的化疗效果，同时降低毒性。

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Grouped product items
规格	价格	库存
1mg	¥1,925.00	现货
5mg	¥1,225.00	现货
10mg	¥2,415.00	现货
25mg	¥4,165.00	现货
50mg	¥6,965.00	现货
更大包装	更多折扣

大包装询价

Notify me when the price drops

全国免运费, 顺丰次日达

重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Folitixorin (ANX-510)发表的1篇文献

Chern Chiuh Woo, .et al. , Oncotarget, 2016, Aug 16; 7(33): 53005-53017 PMID: 27391339

生物活性

Discription

ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Unlike leucovorin, MTHF, as the active form of folate, does not require metabolic activation and may increase the chemotherapeutic effects of fluorouracil with lower toxicity.

产品信息

目录号	A12370
分子式	C20H23N7O6
分子量	457.44
CAS号	3432-99-3
SMILES	C1C2CN(CN2C3=C(N1)NC(=NC3=O)N)C4=CC=C(C=C4)C(=O)N[C@@H](CCC(=O)O)C(=O)O
其他名称	ANX510; CoFactor; 5,10-methylenetetrahydrofolate; 5,10-Methylene-5,6,7,8-tetrahydrofolate; 5,10-MTHF; MTHF
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords: 购买 Folitixorin (ANX-510) | Folitixorin (ANX-510) 供应商 | Folitixorin (ANX-510) 花费 | Folitixorin (ANX-510) 生产商 | 订购 Folitixorin (ANX-510) | Folitixorin (ANX-510) 代理商 | 购买 3432-99-3 | 3432-99-3 供应商 | 3432-99-3 花费 | 3432-99-3 生产商 | 订购 3432-99-3 | 3432-99-3 代理商