AP1903

目录号: A13519

AP1903 Chemical Structure

CAS NO. 195514-63-7

AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity.

库存: 现货

规格 价格 数量
5 mg
¥ 3,500.00
10 mg
¥ 5,100.00
25 mg
¥ 9,800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

AP1903 is a lipid-permeable tacrolimus analogue with homodimerizing activity. Dimerizer drug AP1903 homodimerizes an analogue of human protein FKBP12 (Fv) which contains a single acid substitution (Phe36Val) so that AP1903 binds to wild-type FKBP12 with 1000-fold lower affinity.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 7.08 mL 35.42 mL 70.84 mL
0.5 mM 1.42 mL 7.08 mL 14.17 mL
1 mM 0.71 mL 3.54 mL 7.08 mL
5 mM 0.14 mL 0.71 mL 1.42 mL

*The above data is based on the productmolecular weight 1411.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13519
MECHANISM OF ACTION
M. Wt 1411.63
Formula C78H98N4O20
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 195514-63-7
Synonyms AP 1903, AP-1903
SMILES CC[C@@H](C1=CC(=C(C(=C1)OC)OC)OC)C(=O)N2CCCC[C@H]2C(=O)O[C@H](CCC3=CC(=C(C=C3)OC)OC)C4=CC(=CC=C4)OCC(=O)NCCNC(=O)COC5=CC=CC(=C5)[C@@H](CCC6=CC(=C(C=C6)OC)OC)OC(=O)[C@@H]7CCCCN7C(=O)[C@@H](CC)C8=CC(=C(C(=C8)OC)OC)OC

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