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API-1 (NSC 177223) is a potent inhibitor of Akt that induces GSK3-dependent, β-TrCP- and FBXW7-mediated Mcl-1 degradation, resulting in induction of apoptosis.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 29.65 mL | 148.24 mL | 296.48 mL |
| 0.5 mM | 5.93 mL | 29.65 mL | 59.3 mL |
| 1 mM | 2.96 mL | 14.82 mL | 29.65 mL |
| 5 mM | 0.59 mL | 2.96 mL | 5.93 mL |
*The above data is based on the productmolecular weight 337.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22093 |
|---|---|
| M. Wt | 337.29 |
| Formula | C13H15N5O6 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 36707-00-3 |
| Synonyms | API1; API 1; NSC177233. |
| SMILES | O=C(C1=CN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C3=NC=NC(N)=C3C1=O)N |
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