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Apigenin

促销

Protein kinase 抑制剂

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产品目录号: A10081

库存状态:中国现货中国现货

产品名 目录号 价格 数量
Apigenin 50mg A10081-50
¥ 600.00
Apigenin 100mg A10081-100
¥ 1,000.00
Apigenin 200mg A10081-200
¥ 1,800.00
Apigenin 10mM * 1mL in DMSO A10081-10mM-D
¥ 620.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

Apigenin, found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally-occurring glycosides. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property. Apigenin is a ligand for central benzodiazepine receptors that competitively inhibited the binding of flunitrazepam with a Ki of 4μM, exerting anxiolytic and slight sedative effects.

Apigenin

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Chemical Information

目录号 A10081
Mechanism of action Inhibitor
分子量 270.2
化学分子式 C15H10O5
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 520-36-5
Synonyms 4’,5,7-trihydroxyflavone
SMILES code C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)O
化学名称 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

生物活性

Description

Apigenin, found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally-occurring glycosides. Apigenin acts as a monoamine transporter activator, one of the few chemicals demonstrated to possess this property. Apigenin is a ligand for central benzodiazepine receptors that competitively inhibited the binding of flunitrazepam with a Ki of 4μM, exerting anxiolytic and slight sedative effects.

Targets
CYP2C9
2 μM(Ki)

溶解性

Solubility (25°C)* In vitro DMSO 54 mg/mL (199.82 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.01 mL 185.05 mL 370.1mL
0.5 mM 7.4 mL 37.01 mL 74.02 mL
1 mM 3.7 mL 18.5 mL 37.01 mL
5 mM 0.74 mL 3.7 mL 7.4 mL

*The above data is based on the productmolecular weight 270.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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