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Apilimod (STA 5326) mesylate is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.37 mL | 81.87 mL | 163.75 mL |
| 0.5 mM | 3.27 mL | 16.37 mL | 32.75 mL |
| 1 mM | 1.64 mL | 8.19 mL | 16.37 mL |
| 5 mM | 0.33 mL | 1.64 mL | 3.27 mL |
*The above data is based on the productmolecular weight 610.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22049 |
|---|---|
| M. Wt | 610.7 |
| Formula | C25H34N6O8S2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 870087-36-8 |
| Synonyms | STA 5326 mesylate |
| SMILES | CC1=CC=CC(/C=N/NC2=CC(N3CCOCC3)=NC(OCCC4=CC=CC=N4)=N2)=C1.CS(=O)(O)=O.CS(=O)(O)=O |
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