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(+)-Apogossypol

Bcl-2 family 抑制剂

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产品目录号: A16316

库存状态:中国现货中国现货

产品名 目录号 价格 数量
(+)-Apogossypol 5mg A16316-5
¥ 3,200.00
(+)-Apogossypol 10mg A16316-10
¥ 5,800.00
(+)-Apogossypol 50mg A16316-50
¥ 16,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

(+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins; competing with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 μM.

(+)-Apogossypol

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Chemical Information

目录号 A16316
Mechanism of action Inhibitor
分子量 462.53
化学分子式 C28H30O6
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 66389-74-0
Synonyms Apogossypol, NSC736630
SMILES code CC(C=C1C(C(C)C)=C(O)C(O)=CC1=C2O)=[C@]2[C@@]3=C(C)C=C4C(C=C(O)C(O)=C4C(C)C)=C3O
化学名称 (R)-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',6,6',7,7'-hexaol

生物活性

Description
(+)-Apogossypol is a potent inhibitor of Bcl-2 family proteins; competing with the BH3 peptide-binding sites on Bcl-2, Bcl-XL, Mcl-1, Bcl-W, and Bcl-B, but not Bfl-1, with IC50s of 0.5 to 2 μM.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.62 mL 108.1 mL 216.2mL
0.5 mM 4.32 mL 21.62 mL 43.24 mL
1 mM 2.16 mL 10.81 mL 21.62 mL
5 mM 0.43 mL 2.16 mL 4.32 mL

*The above data is based on the productmolecular weight 462.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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