AR-A 014418

目录号: A13728

GSK-3 inhibitor

AR-A 014418 Chemical Structure

CAS NO. 487021-52-3

AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.

库存: 现货

规格 价格 数量
10 mg
¥ 600.00
25 mg
¥ 1,200.00
50 mg
¥ 2,000.00
100 mg
¥ 3,500.00
10mM * 1mL in DMSO
¥ 600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
Targets
GSK-3β (Cell-free assay) GSK-3β (Cell-free assay)
38 nM(Ki)38 nM(Ki)
In vitro DMSO 62 mg/mL (201.09 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.43 mL 162.17 mL 324.35 mL
0.5 mM 6.49 mL 32.43 mL 64.87 mL
1 mM 3.24 mL 16.22 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL

*The above data is based on the productmolecular weight 308.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13728
MECHANISM OF ACTION Inhibitor
M. Wt 308.31
Formula C12H12N4O4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 487021-52-3
Synonyms AR-A014418, ARA 014418, ARA014418
SMILES COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]

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