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AR-A 014418

促销

GSK-3 抑制剂

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产品目录号: A13728

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AR-A 014418 10mg A13728-10
¥ 600.00
AR-A 014418 25mg A13728-25
¥ 1,200.00
AR-A 014418 50mg A13728-50
¥ 2,000.00
AR-A 014418 100mg A13728-100
¥ 3,500.00
AR-A 014418 10mM * 1mL in DMSO A13728-10mM-D
¥ 600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.

AR-A 014418

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Chemical Information

目录号 A13728
Mechanism of action Inhibitor
分子量 308.31
化学分子式 C12H12N4O4S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 487021-52-3
Synonyms AR-A014418, ARA 014418, ARA014418
SMILES code COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]
化学名称 N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea

生物活性

Description
AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
Targets
GSK-3β (Cell-free assay) GSK-3β (Cell-free assay)
38 nM(Ki)38 nM(Ki)

溶解性

Solubility (25°C)* In vitro DMSO 62 mg/mL (201.09 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.43 mL 162.17 mL 324.35mL
0.5 mM 6.49 mL 32.43 mL 64.87 mL
1 mM 3.24 mL 16.22 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL

*The above data is based on the productmolecular weight 308.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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