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AR-C155858

MCT1 and MCT2 抑制剂

125 Customer Reviews
产品目录号: A11293

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AR-C155858 5mg A11293-5
¥ 3,100.00
AR-C155858 10mg A11293-10
¥ 5,200.00
AR-C155858 25mg A11293-25
¥ 10,000.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.

AR-C155858

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Chemical Information

目录号 A11293
Mechanism of action Inhibitor
分子量 461.5
化学分子式 C21H27N5O5S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 496791-37-8
Synonyms AR-C 155858
SMILES code CC1=C(C(=NN1)C)CC2=C(C3=C(S2)N(C(=O)N(C3=O)C)CC(C)C)C(=O)N4C[C@@H](CO4)O
化学名称 (S)-6-[(3,5-Dimethyl-1H-pyrazol-4-yl)methyl]-5-[(4-hydroxyisoxazolidin-2-yl)carbonyl]-1-isobutyl-3-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

Biological Activity

Description
AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.

General References

1. Ovens et al (2010) The inhibition of monocarboxylate transporter 2 (MCT2) by AR-C155858 is modulated by the associated ancillary protein. Biochem.J. 431 217. PMID: 20695846.
2.Ovens et al (2010) AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem.J. 425 523. PMID: 19929853.

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