Apalutamide (ARN-509)

Name: Apalutamide (ARN-509)
SKU: A11923

目录号: A11923

Androgen Receptor 抑制剂

Product Citations (1)

Apalutamide (ARN-509) Chemical Structure

CAS NO. 956104-40-8

Apalutamide (ARN-509)是一种具有潜在抗肿瘤活性的雄激素受体拮抗剂，IC50 为 16 nM。ARN-509与靶组织中的AR结合，从而阻止了雄激素诱导的受体激活，并促进了无法转运至细胞核的无活性复合物的形成。这防止了AR应答基因的结合和转录。

库存：现货

规格	价格	数量
5 mg	￥ 700.00
10 mg	￥ 1,200.00
25 mg	￥ 2,400.00
50 mg	￥ 3,500.00
10mM * 1mL in DMSO	￥ 750.00

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生物活性

靶点信息

Androgen Receptor (Cell-free assay)	GABAA receptor (Cell-free assay)
16 nM	3 μM

溶解度 *

In vitro (25°C)	DMSO	18 mg/mL (37.7 mM)
	Water	Insoluble
	Ethanol	5 mg/mL (10.47 mM)
In vivo	2% DMSO+40% PEG 300+2% Tween 80+ddH2O	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.95 mL	104.73 mL	209.47 mL
0.5 mM	4.19 mL	20.95 mL	41.89 mL
1 mM	2.09 mL	10.47 mL	20.95 mL
5 mM	0.42 mL	2.09 mL	4.19 mL

*The above data is based on the productmolecular weight 477.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11923
作用机制	Inhibitor (抑制剂)
M. Wt	477.4
Formula	C21H15F4N5O2S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	956104-40-8
Synonyms	ARN509
SMILES	CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CN=C(C(=C4)C(F)(F)F)C#N)F