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Apalutamide (ARN-509)

促销

Androgen Receptor 抑制剂

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产品目录号: A11923

库存状态:中国现货中国现货

产品名 目录号 价格 数量
ARN-509 5mg A11923-5
¥ 700.00
ARN-509 10mg A11923-10
¥ 1,200.00
ARN-509 25mg A11923-25
¥ 2,400.00
ARN-509 50mg A11923-50
¥ 3,500.00
ARN-509 10mM * 1mL in DMSO A11923-10mM-D
¥ 750.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes.

Apalutamide (ARN-509)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Apalutamide (ARN-509) 发表的文献 (1)
  • Fr谷d谷rique Mittler, .et al. High-Content Monitoring of Drug Effects in a 3D Spheroid Model, Front Oncol, 2017, 7: 293 PMID: 29322028

Chemical Information

目录号 A11923
Mechanism of action Inhibitor
分子量 477.4
化学分子式 C21H15F4N5O2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 956104-40-8
Synonyms ARN509
SMILES code CNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CN=C(C(=C4)C(F)(F)F)C#N)F
化学名称 4-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)-2-fluoro-N-methylbenzamide

生物活性

Description
ARN-509 is an androgen receptor antagonist with potential antineoplastic activity. ARN-509 binds to AR in target tissues thereby preventing androgen-induced receptor activation and facilitating the formation of inactive complexes that cannot be translocated to the nucleus. This prevents binding to and transcription of AR-responsive genes.
Targets
Androgen Receptor (Cell-free assay) GABAA receptor (Cell-free assay)
16 nM3 μM

溶解性

Solubility (25°C) * In vitro DMSO 18 mg/mL (37.7 mM)
Water <1 mg/mL (<1 mM)
Ethanol 5 mg/mL (10.47 mM)
In vivo 0.5% CMC, pH4.0 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.95 mL 104.73 mL 209.47mL
0.5 mM 4.19 mL 20.95 mL 41.89 mL
1 mM 2.09 mL 10.47 mL 20.95 mL
5 mM 0.42 mL 2.09 mL 4.19 mL

*The above data is based on the productmolecular weight 477.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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