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ARRY-543 (Varlitinib,ASLAN001)是一种新型口服ErbB家族抑制剂，与批准的ErbB抑制剂不同，它直接或间接靶向ErbB家族的所有成员，包括ErbB3，在治疗通过多个ErbB家族成员发出信号的肿瘤方面具有潜在优势。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.85 mL | 64.25 mL | 128.51 mL |
| 0.5 mM | 2.57 mL | 12.85 mL | 25.7 mL |
| 1 mM | 1.29 mL | 6.43 mL | 12.85 mL |
| 5 mM | 0.26 mL | 1.29 mL | 2.57 mL |
*The above data is based on the productmolecular weight 778.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12868 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 778.15 |
| Formula | N/A |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 114629-86-8 |
| Synonyms | ARRY543,ARRY 543 |
| SMILES | ClC1=CC(NC2=NC=NC3=CC=C(NC4=N[C@H](C)CO4)C=C32)=CC=C1OCC5=NC=CS5.CC6=CC=C(S(O)=O)C=C6.CC7=CC=C(S(O)=O)C=C7 |
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