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ARS-853

产品详情

ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. ARS-853 inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation.

溶解度 *

In vitro	DMSO	Warmed: 80 mg/mL (184.78 mM)
	Water	Insoluble
	Ethanol	Warmed: 1 mg/mL (2.3 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.1 mL	115.49 mL	230.98 mL
0.5 mM	4.62 mL	23.1 mL	46.2 mL
1 mM	2.31 mL	11.55 mL	23.1 mL
5 mM	0.46 mL	2.31 mL	4.62 mL

*The above data is based on the productmolecular weight 432.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12542
作用机制	Inhibitor (抑制剂)
M. Wt	432.94
Formula	C22H29ClN4O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1629268-00-3
Synonyms	ARS853, ARS 853
SMILES	ClC1=C(C2(C)CC2)C=C(NCC(N3CCN(C4CN(C(C=C)=O)C4)CC3)=O)C(O)=C1