产品详情

生物活性

ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.

溶解度 *

In vitro	DMSO	97 mg/mL (98.31 mM)
	Water	Insoluble
	Ethanol	97 mg/mL (98.31 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	10.14 mL	50.68 mL	101.35 mL
0.5 mM	2.03 mL	10.14 mL	20.27 mL
1 mM	1.01 mL	5.07 mL	10.14 mL
5 mM	0.2 mL	1.01 mL	2.03 mL

*The above data is based on the productmolecular weight 986.64. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13255
作用机制	Degrader (降解剂)
M. Wt	986.64
Formula	C49H60ClN9O7S2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1949837-12-0
Synonyms	ARV771, ARV 771
SMILES	CC(C(C(C1=CC=C(Cl)C=C1)=N[C@@H](CC(NCCOCCCOCC(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C2)[C@@H]2C(N[C@H](C3=CC=C(C(SC=N4)=C4C)C=C3)C)=O)=O)=O)=O)C5=NN=C(C)N65)=C6S7)=C7C