AS-252424

目录号: A11099

PI3K inhibitor

AS-252424 Chemical Structure

CAS NO. 900515-16-4

AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ, α, β, and δ with IC50 values of 30, 940, 20,000, and 20,000 nM respectively.

库存: 现货

规格 价格 数量
5 mg
¥ 600.00
10 mg
¥ 1,000.00
50 mg
¥ 4,000.00
100 mg
¥ 6,500.00
10mM * 1mL in DMSO
¥ 960.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

AS-252424 is a potent inhibitor of PI3K with selectivity for the γ isoform. It inhibits human recombinant PI3Kγ, α, β, and δ with IC50 values of 30, 940, 20,000, and 20,000 nM respectively.
Targets
Casein Kinase 2 (Cell-free assay) PI3Kγ (Cell-free assay) PI3Kα (Cell-free assay)
20 nM33 nM935 nM
In vitro (25°C) DMSO 61 mg/mL (199.81 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC/0.25% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.75 mL 163.77 mL 327.55 mL
0.5 mM 6.55 mL 32.75 mL 65.51 mL
1 mM 3.28 mL 16.38 mL 32.75 mL
5 mM 0.66 mL 3.28 mL 6.55 mL

*The above data is based on the productmolecular weight 305.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11099
MECHANISM OF ACTION Inhibitor
M. Wt 305.3
Formula C14H8FNO4S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 900515-16-4
Synonyms AS252424
SMILES C1=CC(=C(C=C1F)O)C2=CC=C(O2)/C=C\3/C(=O)NC(=O)S3

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