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AS-604850抑制MCP-1介导的单核细胞趋化性，IC50值为21 ?M，并在ED50值为42.4 mg/kg的白细胞趋化性小鼠模型中降低了RANTES诱导的腹膜中性粒细胞募集。
| In vitro (25°C) | DMSO | 49 mg/mL (171.79 mM) | |
| Water | Insoluble | ||
| Ethanol | 4 mg/mL (14.02 mM) | ||
| In vivo | 0.5% CMC+0.25% Tween 80 | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.06 mL | 175.3 mL | 350.61 mL |
| 0.5 mM | 7.01 mL | 35.06 mL | 70.12 mL |
| 1 mM | 3.51 mL | 17.53 mL | 35.06 mL |
| 5 mM | 0.7 mL | 3.51 mL | 7.01 mL |
*The above data is based on the productmolecular weight 285.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11197 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 285.22 |
| Formula | C11H5F2NO4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 648449-76-7 |
| Synonyms | AS604850 |
| SMILES | CCC1=COC2=CC(=O)C=C(C2=C1O)O |
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