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AS-605240

PI3K 抑制剂

158 Customer Reviews
产品目录号: A10088

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AS-605240 10mg A10088-10
¥ 400.00
AS-605240 25mg A10088-25
¥ 1,000.00
AS-605240 50mg A10088-50
¥ 1,800.00
AS-605240 100mg A10088-100
¥ 2,600.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AS-605240 is an orally active inhibitor of PI3-kinase γ that inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively.

AS-605240

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Chemical Information

目录号 A10088
Mechanism of action Inhibitor
分子量 257.3
化学分子式 C12H7N3O2S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 648450-29-7
Synonyms AS605240
SMILES code C1=CC2=NC=CN=C2C=C1/C=C\3/C(=O)NC(=O)S3
化学名称 5-(6-Quinoxalinylmethylene)-2,4-thiazolidine-2,4-dione

生物活性

Description
AS-605240 is an orally active inhibitor of PI3-kinase γ that inhibits human recombinant PI3Kγ, α, β, and δ in an ATP-competitive manner with IC50 values of 8, 60, 270, and 300 nM, respectively.
Targets
PI3Kγ (Cell-free assay) PI3Kα (Cell-free assay) PI3Kβ (Cell-free assay) PI3Kδ (Cell-free assay)
8 nM60 nM270 nM300 nM

溶解性

Solubility (25°C) * In vitro DMSO 0.4 mg/mL (1.55 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 0.5% CMC/0.25% Tween 80 11 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 38.87 mL 194.33 mL 388.65mL
0.5 mM 7.77 mL 38.87 mL 77.73 mL
1 mM 3.89 mL 19.43 mL 38.87 mL
5 mM 0.78 mL 3.89 mL 7.77 mL

*The above data is based on the productmolecular weight 257.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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