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AS1949490 is a potent and selective SHIP-2 (SH2 domain-containing inositol 5?? phosphatase 2) inhibitor, with an IC50 of 620 nM. AS1949490 activated glucose metabolism via up-regulation of GLUT1 gene in L6 myotubes.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.89 mL | 134.45 mL | 268.9 mL |
| 0.5 mM | 5.38 mL | 26.89 mL | 53.78 mL |
| 1 mM | 2.69 mL | 13.45 mL | 26.89 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.38 mL |
*The above data is based on the productmolecular weight 371.88. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20847 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 371.88 |
| Formula | C20H18ClNO2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1203680-76-5 |
| Synonyms | AS 194949, AS-194949 |
| SMILES | O=C(C1=C(OCC2=CC=C(Cl)C=C2)C=CS1)N[C@H](C3=CC=CC=C3)C |
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