AS703026 (Pimasertib)
目录号: A10089
MEK1/2 抑制剂
AS703026 是一种新型、选择性、口服生物利用度的 MEK1/2 抑制剂,它能抑制 MM 细胞的生长和存活,以及细胞因子诱导的破骨细胞分化。
Discription | AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation. | ||
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目录号 | A10089 |
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分子式 | C15H15FIN3O3 |
分子量 | 431.2 |
CAS号 | 1236699-92-5 |
SMILES | C1=CC(=C(C=C1I)F)NC2=C(C=CN=C2)C(=O)NC[C@@H](CO)O |
其他名称 | MSC1936369B |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | 78 mg/mL (180.89 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 0.5% CMC+0.25% Tween 80 | 28 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 23.19 mL | 115.96 mL | 231.91 mL |
0.5 mM | 4.64 mL | 23.19 mL | 46.38 mL |
1 mM | 2.32 mL | 11.6 mL | 23.19 mL |
5 mM | 0.46 mL | 2.32 mL | 4.64 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2