Aselizumab (HuDreg-55) is a humanized IgG4 monoclonal antibody targeting L-selectin (CD62L), a cell adhesion molecule predominantly expressed on circulating neutrophils. L-selectin facilitates the migration of these cells to sites of injury via chemotaxis. Due to its mechanism of action, Aselizumab has been associated with an increased incidence of infections and leukopenia following trauma. This antibody is pivotal for research into immune response modulation and the potential therapeutic management of inflammatory conditions.
Aselizumab (HuDreg-55) is a humanized IgG4 monoclonal antibody targeting L-selectin (CD62L), a cell adhesion molecule predominantly expressed on circulating neutrophils. L-selectin facilitates the migration of these cells to sites of injury via chemotaxis. Due to its mechanism of action, Aselizumab has been associated with an increased incidence of infections and leukopenia following trauma. This antibody is pivotal for research into immune response modulation and the potential therapeutic management of inflammatory conditions.
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