Asenapine maleate

目录号: A10091

H1 antagonist

Asenapine maleate

Asenapine maleate Chemical Structure

CAS NO. 85650-56-2

Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5A (8.8), 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic α1 (8.9), α2A (8.9), α2B (9.5), and α2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors.

库存: 现货

规格 价格 数量
25 mg
¥ 800.00
50 mg
¥ 1,000.00
100 mg
¥ 1,500.00
200 mg
¥ 2,500.00
10mM * 1mL in DMSO
¥ 720.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5A (8.8), 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic α1 (8.9), α2A (8.9), α2B (9.5), and α2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors.
Targets
Target Value
5-HT2Cpki: 10.46
5-HT2Apki: 10.15
5-HT7pki: 9.94
5-HT2Bpki: 9.75
5-HT6pki: 9.6
α2B-adrenergicreceptorpki: 9.49
D3receptorpki: 9.38
H1receptorpki: 9
D4receptorpki: 8.95
α1A-adrenergicreceptorpki: 8.93
α2C-adrenergicreceptorpki: 8.91
D2LReceptorpki: 8.9
α2A-adrenergicreceptorpki: 8.9
D1receptorpki: 8.85
5-HT5Apki: 8.84
D2SReceptorpki: 8.84
5-HT1Apki: 8.6
5-HT1Bpki: 8.4
H2receptorpki: 8.21
In vitro DMSO 80 mg/mL (199.08 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.89 mL 124.43 mL 248.86 mL
0.5 mM 4.98 mL 24.89 mL 49.77 mL
1 mM 2.49 mL 12.44 mL 24.89 mL
5 mM 0.5 mL 2.49 mL 4.98 mL

*The above data is based on the productmolecular weight 401.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A10091
MECHANISM OF ACTION Antagonist
M. Wt 401.84
Formula C17H16ClNO.C4H4O4
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 85650-56-2
Synonyms N/A
SMILES CN1C[C@H]2[C@H](C1)C3=C(C=CC(=C3)Cl)OC4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O

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