Astemizole

目录号: A13899

H1-receptor antagonist

Astemizole Chemical Structure

CAS NO. 68844-77-9

Astemizole is a potent antihistamine (H1-receptor antagonist, IC50 = 4 nM) that displays selectivity over dopamine, 5-HT, and muscarinic acetylcholine receptors. This compound has shown potent hERG K+ channel blocking activity (IC50 = 0.9 nM), antimalarial activity in multidrug resistant strains in vitro (IC50 = 227 - 734 nM), and has been used as a chaperone to correct folding defects and restore protein function for some mutated forms of hERG channels.

库存: 现货

规格 价格 数量
100 mg
¥ 1,400.00
500 mg
¥ 4,200.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

Astemizole is a potent antihistamine (H1-receptor antagonist, IC50 = 4 nM) that displays selectivity over dopamine, 5-HT, and muscarinic acetylcholine receptors. This compound has shown potent hERG K+ channel blocking activity (IC50 = 0.9 nM), antimalarial activity in multidrug resistant strains in vitro (IC50 = 227 - 734 nM), and has been used as a chaperone to correct folding defects and restore protein function for some mutated forms of hERG channels.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.81 mL 109.03 mL 218.07 mL
0.5 mM 4.36 mL 21.81 mL 43.61 mL
1 mM 2.18 mL 10.9 mL 21.81 mL
5 mM 0.44 mL 2.18 mL 4.36 mL

*The above data is based on the productmolecular weight 458.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A13899
MECHANISM OF ACTION Antagonist
M. Wt 458.57
Formula C28H31FN4O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 68844-77-9
Synonyms Astemisan, Hismanal, Histamen, Paralergim
SMILES COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F

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