Xevinapant (AT-406, SM-406, ARRY-334543)

Name: Xevinapant (AT-406, SM-406, ARRY-334543)
SKU: A11163
Price: 210 CNY
Rating: 5 (2 reviews)

目录号: A11163

IAP 抑制剂

2 篇发表文献

AT-406 是一种口服生物可用的 IAP家族蛋白 抑制剂，具有潜在的诱导凋亡和抗肿瘤活性。AT-406 选择性地抑制 IAP蛋白 的生物活性，包括 X染色体连锁IAP（XIAP）、细胞IAPs 1（c-IAP1）和2（c-IAP2）以及黑色素瘤凋亡抑制蛋白（ML-IAP）。

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Xevinapant (AT-406, SM-406, ARRY-334543)

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Grouped product items
规格	价格	库存
1mg	¥210.00	现货
2mg	¥315.00	现货
5mg	¥560.00	现货
10mg	¥875.00	现货
25mg	¥1,995.00	现货
50mg	¥3,815.00	现货
100mg	¥5,460.00	现货
200mg	¥7,385.00	现货
500mg	¥9,695.00	现货
*10mM 1mL in DMSO**	¥980.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Xevinapant (AT-406, SM-406, ARRY-334543)发表的2篇文献

Yoshikawa M, .et al. , J Med Chem, 2018, Mar 22;61(6):2384-2409 PMID: 29485864

Tsuyoshi Ishii, .et al. , Sci Rep, 2017, 7: 13000 PMID: 29026104

生物活性

Discription

AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP).

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11163
分子式	C32H43N5O4
分子量	561.71
CAS号	1071992-99-8
SMILES	C[C@@H](C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C)NC
其他名称	AT406, SM-406, ARRY-334543
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	85 mg/mL (151.32 mM)
	Water	Insoluble
	Ethanol	85 mg/mL (151.32 mM)
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.8 mL	89.01 mL	178.03 mL
0.5 mM	3.56 mL	17.8 mL	35.61 mL
1 mM	1.78 mL	8.9 mL	17.8 mL
5 mM	0.36 mL	1.78 mL	3.56 mL

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