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AT-406 (SM-406, ARRY-334543)

促销

IAP 抑制剂

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产品目录号: A11163

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AT-406 5mg A11163-5
¥ 900.00
AT-406 10mg A11163-10
¥ 1,600.00
AT-406 50mg A11163-50
¥ 5,000.00
AT-406 200mg A11163-200
¥ 16,500.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP).

AT-406 (SM-406, ARRY-334543)

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 AT-406 (SM-406, ARRY-334543) 发表的文献 (2)
  • Yoshikawa M, .et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships, J Med Chem, 2018, Mar 22;61(6):2384-2409 PMID: 29485864
  • Tsuyoshi Ishii, .et al. CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens, Sci Rep, 2017, 7: 13000 PMID: 29026104

Chemical Information

目录号 A11163
Mechanism of action Inhibitor
分子量 561.71
化学分子式 C32H43N5O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 1071992-99-8
Synonyms AT406, SM-406, ARRY-334543
SMILES code C[C@@H](C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C)NC
化学名称 (5S,8S,10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide

生物活性

Description
AT-406 is an orally bioavailable inhibitor of IAP family of proteins with potential apoptotic inducing and antineoplastic activity. AT-406 selectively inhibits the biological activity of IAP proteins, including X chromosome-linked IAP (XIAP), the cellular IAPs 1 (c-IAP1) and 2 (c-IAP2) and melanoma inhibitor of apoptosis protein (ML-IAP).

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.8 mL 89.01 mL 178.03mL
0.5 mM 3.56 mL 17.8 mL 35.61 mL
1 mM 1.78 mL 8.9 mL 17.8 mL
5 mM 0.36 mL 1.78 mL 3.56 mL

*The above data is based on the productmolecular weight 561.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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