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Onalespib (AT13387)


HSP90 抑制剂

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产品目录号: A11062


产品名 目录号 价格 数量
AT13387 5mg A11062-5
¥ 900.00
AT13387 10mg A11062-10
¥ 1,500.00
AT13387 50mg A11062-50
¥ 3,500.00
AT13387 100mg A11062-100
¥ 5,700.00
AT13387 10mM * 1mL in DMSO A11062-10mM-D
¥ 950.00



AT13387 is a targeted inhibitor of Hsp90,inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival.

Onalespib (AT13387)




顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 Onalespib (AT13387) 发表的文献 (3)
  • Boucherat O, .et al. Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension, Am J Respir Crit Care Med, 2018, Jul 1;198(1):90-103 PMID: 29394093
  • Olivier Boucherat, .et al. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension, Sci Rep, 2017, 7: 4546 PMID: 28674407
  • Hiroki Murano, .et al. A purine-type heat shock protein 90 inhibitor promotes the heat shock response in Arabidopsis, Plant Biotechnol Rep, 2017, 11:107每113

Chemical Information

目录号 A11062
Mechanism of action Inhibitor
分子量 409.5
化学分子式 C24H31N3O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 912999-49-6
Synonyms AT-13387
SMILES code CC(C)C1=C(C=C(C(=C1)C(=O)N2CC3=C(C2)C=C(C=C3)CN4CCN(CC4)C)O)O
化学名称 (2,4-dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone


AT13387 is a targeted inhibitor of Hsp90,inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival.
HSP90 (Cell-free assay)
18 nM


Solubility (25°C) * In vitro DMSO 25 mg/mL (61.04 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.42 mL 122.1 mL 244.2mL
0.5 mM 4.88 mL 24.42 mL 48.84 mL
1 mM 2.44 mL 12.21 mL 24.42 mL
5 mM 0.49 mL 2.44 mL 4.88 mL

*The above data is based on the productmolecular weight 409.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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