AT7519 HCl

目录号: A11313

CDK inhibitor

AT7519 HCl Chemical Structure

CAS NO. 902135-91-5

AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.

库存: 现货

规格 价格 数量
5 mg
¥ 550.00
10 mg
¥ 800.00
25 mg
¥ 1,200.00
50 mg
¥ 1,700.00
10mM * 1mL in DMSO
¥ 600.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

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AT7519 is an inhibitor of multiple cyclin-dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation.
Targets
Target Value
CDK9/CyclinTIC50: <10nM
CDK5/p35IC50: 13nM
CDK2/CyclinAIC50: 47nM
GSK-3βIC50: 89nM
CDK4/CyclinD1IC50: 100nM
CDK6/CyclinD3IC50: 170nM
CDK1/CyclinBIC50: 210nM
CDK3/CyclinEIC50: 360nM
PI3KβIC50: >1μM
PLK3IC50: >1μM
RETIC50: >1μM
SGKIC50: >1μM
TrkBIC50: >1μM
JAK2IC50: >1μM
CDK7/CyclinH/MAT1IC50: 2.4μM
SAPK2A(p38α)IC50: >10μM
p70S6KIC50: >10μM
PDGFRIC50: >10μM
PDK-1IC50: >10μM
PKBβIC50: >10μM
VEGFR1IC50: >10μM
AuroraAIC50: >10μM
c-AblIC50: >10μM
c-SrcIC50: >10μM
Chk1IC50: >10μM
EGFRIC50: >10μM
FGFR3IC50: >10μM
IRIC50: >10μM
JNK2IC50: >10μM
MAPK1IC50: >10μM
MEK1IC50: >10μM
MetIC50: >10μM
In vitro (25°C) DMSO 10 mg/mL (26.16 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.88 mL 119.42 mL 238.83 mL
0.5 mM 4.78 mL 23.88 mL 47.77 mL
1 mM 2.39 mL 11.94 mL 23.88 mL
5 mM 0.48 mL 2.39 mL 4.78 mL

*The above data is based on the productmolecular weight 418.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11313
MECHANISM OF ACTION Inhibitor
M. Wt 418.7
Formula C16H17Cl2N5O2.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 902135-91-5
Synonyms AT 7519, AT-7519
SMILES C1CNCCC1NC(=O)C2=C(C=NN2)NC(=O)C3=C(C=CC=C3Cl)Cl.Cl

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