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AKT 抑制剂

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产品目录号: A10094


产品名 目录号 价格 数量
AT7867 10mg A10094-10
¥ 1,500.00
AT7867 25mg A10094-25
¥ 3,500.00
AT7867 50mg A10094-50
¥ 6,000.00
AT7867 100mg A10094-100
¥ 9,500.00
AT7867 10mM * 1mL in DMSO A10094-10mM-D
¥ 1,470.00



AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.





顾客使用 Adooq 产品发表的高质量科研文献

Chemical Information

目录号 A10094
Mechanism of action Inhibitor
分子量 337.9
化学分子式 C20H20ClN3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 857531-00-1
Synonyms AT-7867
化学名称 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine


AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.
Target Value
Akt2IC50: 17nM
PKAIC50: 20nM
Akt1IC50: 32nM
Akt3IC50: 47nM
p70S6KIC50: 85nM
RSK1IC50: >100nM
CDK2IC50: >1μM
GSK-3βIC50: >1μM
c-SrcIC50: >1μM
Chk1IC50: >1μM
EGFRIC50: >1μM
FGFR3IC50: >1μM
MEK1IC50: >1μM
PDK-1IC50: >1μM
PI3KβIC50: >1μM
PLK3IC50: >1μM
RETIC50: >1μM
SGKIC50: >1μM
Tie-2IC50: >1μM


Solubility (25°C) * In vitro DMSO 68 mg/mL (201.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol 5 mg/mL (14.79 mM)
In vivo 15% Captisol, pH 9 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.


Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.59 mL 147.97 mL 295.95mL
0.5 mM 5.92 mL 29.59 mL 59.19 mL
1 mM 2.96 mL 14.8 mL 29.59 mL
5 mM 0.59 mL 2.96 mL 5.92 mL

*The above data is based on the productmolecular weight 337.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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