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AT7867

AKT 抑制剂

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产品目录号: A10094

库存状态:中国现货中国现货

产品名 目录号 价格 数量
AT7867 10mg A10094-10
¥ 1,500.00
AT7867 25mg A10094-25
¥ 3,500.00
AT7867 50mg A10094-50
¥ 6,000.00
AT7867 100mg A10094-100
¥ 9,500.00
AT7867 10mM * 1mL in DMSO A10094-10mM-D
¥ 1,470.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.

AT7867

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Chemical Information

目录号 A10094
Mechanism of action Inhibitor
分子量 337.9
化学分子式 C20H20ClN3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 857531-00-1
Synonyms AT-7867
SMILES code C1CNCCC1(C2=CC=C(C=C2)C3=CNN=C3)C4=CC=C(C=C4)Cl
化学名称 4-(4-Chlorophenyl)-4-[4-(1H-pyrazol-4-yl)phenyl]piperidine

生物活性

Description
AT7867 is a novel and potent inhibitor of both AKT and the downstream kinase p70 S6 kinase (p70S6K) and also of protein kinase A.
Targets
Target Value
Akt2IC50: 17nM
PKAIC50: 20nM
Akt1IC50: 32nM
Akt3IC50: 47nM
p70S6KIC50: 85nM
RSK1IC50: >100nM
CDK2IC50: >1μM
GSK-3βIC50: >1μM
c-SrcIC50: >1μM
Chk1IC50: >1μM
EGFRIC50: >1μM
FGFR3IC50: >1μM
MEK1IC50: >1μM
PDK-1IC50: >1μM
PI3KβIC50: >1μM
PLK3IC50: >1μM
RETIC50: >1μM
SGKIC50: >1μM
Tie-2IC50: >1μM

溶解性

Solubility (25°C) * In vitro DMSO 68 mg/mL (201.27 mM)
Water <1 mg/mL (<1 mM)
Ethanol 5 mg/mL (14.79 mM)
In vivo 15% Captisol, pH 9 10 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 29.59 mL 147.97 mL 295.95mL
0.5 mM 5.92 mL 29.59 mL 59.19 mL
1 mM 2.96 mL 14.8 mL 29.59 mL
5 mM 0.59 mL 2.96 mL 5.92 mL

*The above data is based on the productmolecular weight 337.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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